Polyamines are naturally occurring compounds that play important roles in various cellular processes, including cell growth, differentiation, and aging. Recent scientific studies have shown that polyamines may also play a role in skin aging.
One of the key ways that polyamines affect skin aging is by regulating the levels of collagen and elastin, the two proteins that give skin its elasticity and firmness. Collagen and elastin production decreases with age, leading to wrinkles, sagging, and other signs of aging.
A study published in the Journal of Dermatological Science found that treatment with a polyamine, specifically putrescine, increased collagen production in human skin cells in culture. Another study published in the journal Experimental Dermatology showed that topical application of another polyamine, spermidine, led to an increase in collagen and elastin production in mouse skin.
In addition to regulating collagen and elastin production, polyamines also play a key role in thickening the dermis, the middle layer of the skin that provides structure and support. The dermis is responsible for maintaining the skin's elasticity and firmness, and as we age, the dermis naturally becomes thinner. This thinning of the dermis is one of the main causes of wrinkles, sagging skin, and other signs of aging.
Polyamines have been shown to promote the production of extracellular matrix (ECM) components, which make up the dermis. Studies have shown that polyamines such as putrescine and spermidine can increase the production of hyaluronan and glycosaminoglycans (GAGs), key components of the ECM that provide hydration and support to the skin. By promoting the production of these ECM components, polyamines can help to thicken the dermis and provide support to the skin, leading to a more youthful and radiant appearance.
Furthermore, polyamines have been shown to increase the number of fibroblasts, which are the cells that produce collagen and elastin, the two proteins that give skin its elasticity and firmness, making the skin stronger, more elastic and less prone to wrinkles.
The evidence that Polyamines are a super skincare ingredient does not end there. Polyamines also have been shown to have antioxidant and anti-inflammatory effects which can help to protect the skin from damage caused by UV radiation, pollution, and other environmental factors. A study published in the International Journal of Molecular Sciences found that topical application of spermidine led to a reduction in UV-induced oxidative stress and inflammation in mouse skin.
In addition, polyamines also act like growth factors and have been found to promote wound healing.
However, as we age, there is evidence to suggest that the levels of polyamines in the body decrease. A study published in the journal Aging Cell found that the levels of the polyamines putrescine, spermidine, and spermine were significantly lower in older individuals compared to younger individuals. Another study published in the journal Free Radical Biology and Medicine found that the levels of putrescine and spermidine were lower in the skin of older individuals compared to younger individuals. The decrease in polyamine levels with age may contribute to the aging process.
Despite the growing evidence of the anti-aging power of polyamines, there are still only a handful of skincare products utilizing the ingredient. One of the best researched product lines that use polyamine is Vivier's innovative GrenzCine® Growth Factor Solutions. Combining the power of Polyamine-DAB®, Vitamin C, and supporting renewal complexes, the GrenzCine® products offer a multi-layer and multi-function approach to aging skin. This line of skincare products is designed to target multiple signs of aging by addressing the needs of the skin at different layers.
In conclusion, polyamines are naturally occurring compounds that play a crucial role in skin aging. They help regulate collagen and elastin production, have antioxidant and anti-inflammatory effects, and promote wound healing. However, as we age, the levels of polyamines in the body decrease which may contribute to the aging process. Further research is needed to fully understand the relationship between polyamines and aging, and to develop safe and effective ways to maintain or increase polyamine levels in the body as we age.
- J. Dermatol. Sci., Volume 74, Issue 3, pp. 214-222 (2014)
- Experimental Dermatology, Volume 21, Issue 2, pp. 120-126 (2012)
- International Journal of Molecular Sciences, Volume 15, Issue 12, pp. 23107-23120 (2014)
- Aging Cell, Volume 8, Issue 2, pp. 161-170 (2009)
- Free Radical Biology and Medicine, Volume 41, Issue 12, pp. 1803-1809 (2006)