The Future of Hair Growth: PP405 and How to Support Your Scalp Today
Hair restoration science is moving fast — and one of the most intriguing innovations is an investigational topical called PP405, developed with UCLA researchers. PP405 doesn’t block hormones or just increase blood flow; it aims to re-activate dormant hair-follicle stem cells by shifting their cellular energy use.
While PP405 is not yet available, it shines a light on what’s coming next: a future where we don’t only slow loss — we may help wake up follicles that are still viable.
What Is PP405 (In Plain English)?
- What it targets: Dormant hair-follicle stem cells.
- How it works: Adjusts follicle metabolism (the way cells use energy) to nudge follicles from “rest” back into a growth-capable state.
- Why that matters: Hair follicles that haven’t scarred can sometimes be “quiet,” not dead. The goal is to help them function again.
Where It Stands in Canada
PP405 is currently in clinical trials and is not approved by Health Canada. It is not commercially available or prescribed in Canada at this time. Our team monitors these developments closely so we can integrate proven, safe innovations into care the moment they become accessible.
What You Can Do Now: Build a Future-Ready Scalp
You don’t have to wait for tomorrow’s science to support healthier, fuller-looking hair. Here are dermatologist-curated essentials you can start today that complement the regenerative direction of PP405:
1) Keravive® Scalp Spray
Professional-grade daily care inspired by the in-clinic HydraFacial Keravive treatment. Helps gently exfoliate, remove buildup, and deliver hydration and peptides — creating a cleaner, more oxygenated environment for follicles.
Shop Keravive Scalp Spray2) Ducray Neoptide Lotion
A dermatologist recommended treatment that supports hair density and vitality. Ducray Neoptide Lotion targets chronic hair thinning by stimulating the anagen (growth) phase and improving scalp microcirculation. Ideal for men or women seeking a proven natural topical solution while waiting for next-generation options like PP405.
Explore Ducray Neoptide Lotion3) Hair-Support Nutrients
Many patients are surprised to learn that low vitamin D, iron, zinc, and insufficient protein can contribute to shedding. While not a substitute for medical care, targeted supplementation fills common gaps that affect hair quality and growth potential.
Shop Hair Support SupplementsFAQ
Is PP405 available in Canada?
No. PP405 remains under clinical investigation and is not approved by Health Canada. We’ll update our patients as high-quality data emerge and approvals progress.
Can natural remedies mimic PP405?
Some botanicals and lifestyle measures support scalp health and reduce contributing factors (inflammation, buildup, nutrient gaps). However, they do not replicate PP405’s stem-cell metabolic mechanism. We recommend a science-based routine while we await future therapies.
Who benefits most from early intervention?
Patients with early thinning generally respond best to at-home care plus targeted in-clinic treatments. If scarring alopecia is suspected, see our dermatologist promptly for diagnosis and medical management.
The Dermatologie Takeaway
PP405 signals a shift toward regenerative, metabolism-guided hair restoration. Until it’s approved, the smartest move is to optimize your scalp environment and stay consistent with evidence-based care. Our team is here to guide you — from daily products to advanced procedures.
Medical disclaimer: This article is for educational purposes only and is not a substitute for personalized medical advice. Always consult a qualified clinician for diagnosis and treatment.